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Location: Home > Product > Bioreactors > > AppliReact™ series AbioSUS™ single-usebioreactors

AppliReact™ series AbioSUS™ single-usebioreactors

AppliReact™  series  AbioSUS™  single-usebioreactors
The AbioSUS™ single-use bioreactor is integrated with stainless steel tank, disposable reaction bag, and temperature control unit (TCU), providing 50L, 200L, 500L, 1000L, and 2000L cultivation needs. Maintaining the design principles of traditional stirred bioreactors, including specific high diameter ratios and optimized paddle placement, provides optimal cell viability, performance, and scalability from process development to production. It can be widely used in multi-process upstream cell culture in the fields of antibodies, vaccines, cell therapy/gene therapy, etc.
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AbioSUS™ single-use reactor features
1. Switch design, convenient for loading reaction bags;
2. The heating/cooling design of the tank jacket water can realize the heating and cooling of the machine and improve the overall temperature uniformity;
3. Double paddle stirring design, suitable for different volumes of reaction;
4. Support traditional and disposable sensors;
5. Integrated TCU temperature control system, no need for external heating temperature control equipment, with TEC refrigeration anti-overtemperature function;
6. Double aeration port design, providing different foaming specifications. It can effectively increase KLa, improve pH control, and reduce foam formation;

7. The TCU system has an audit trail, conforms to FDA21CFRPart11, is equipped with an external analog signal transmission port, and can be connected to SCADA software with OPC function;


Controller

1. Applikon controller has very good versatility, which can be matched with disposable reactors, glass tanks, stainless steel tanks and other tanks of different sizes and different brands of reaction tanks;
2, 10.4 inch touch screen controller interface, with four levels of operation permissions (View, Operator, Engineer, Service), through different permission management,
Maximum safety of the production process;
3. Applikon controller has pH, DO, temperature, stirring and other control loops, which can set and control a variety of parameters, and the touch screen displays all process parameters;
4. Modular design, suitable for different application scenarios; The process control strategy can be changed, and multiple control loop settings can be provided;
5. Unique PID setting adaptive control function, which can automatically optimize PID, so as to automatically set the best PID parameters to ensure the reproducibility and precise control of experiments;
6. Strong expansion, through the USB port or optional ADDA board, provide additional 8 analog inputs, 4 analog outputs, 8 digital inputs and 8 digital outputs, which can be used to connect Biomass (biomass) controllers, balances, gas analyzers, variable speed pumps and constant speed pump valves and other equipment to the controller;
7. There are a variety of model control options to meet the various needs of customers and achieve personalized configuration.



AbioSUS™ Temperature Control System (TCU)

AbioSUS™ series TCU system can realize three modes: water injection mode, temperature control mode and drainage mode:
Water injection mode: pure water is injected through the quick connector, and the tank jacket and the whole set of TCU unit are filled;
Temperature control mode: the TCU system uses a heater to heat, and the pump circulates hot water to the tank jacket and the tank, thereby maintaining a constant tank temperature; When cooling, an external chiller (chiller equipment) is used, and a heat exchanger is used to cool down;
Drainage mode: use dry and cold compressed air to drain the water in the system;




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