The traditional axial column separation and purification conditions must be constantly optimized with the change of sample size, so it may sacrifice valuable time and resources to explore the conditions. Often, this leads to differences between the products in the initial research phase and those on the market. Scientists at Sepragen invented the Wedge column to solve the problem of the Scale-Up. Under the premise of not affecting the separation effect, efficiency and productivity, the Wedge column makes full use of the medium with high capacity, low cost and faster flow rate to improve the separation capacity. The Wedge column combines the characteristics of the patented radial flow design and the traditional axial flow column, and easily realizes the linear amplification from the laboratory-scale axial column to the large-scale radial flow column.

The Product Features

l  True Linear Easy Scale-Up

l  Easy Validated Packing Procedure

l  High Flow Rates with Soft Media

l  Low Pressure、High Productivity、Higher Yields

l  Consistency in Performance

Case study

The sample volume was scaled-up from 20ml to 600ml, and the magnification was 30 times. In other words, only the column volume was scaled-up in equal proportion ( 400ml to 12L ), and the flow rate was increased in equal proportion ( from 95ml / min to 2850ml / ml ). Easily achieve a consistent purification effect.